OSD-8
NASA Open Science Data Repository
NASA Space Radiation Laboratory (NSRL Brookhaven)
NSRL High-Energy Heavy Ion Accelerator
High-LET Particle Radiation (Fe/Si Ions and Protons)
Arabidopsis thaliana (Col-0)
NSRL: High-LET Heavy Ion Galactic Cosmic Radiation Simulation
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Biological Synopsis & Spaceflight Discoveries
Simulated galactic cosmic ray exposure using heavy relativistic ions (56Fe, 28Si) and proton beams at the NASA Space Radiation Laboratory. Evaluates deep-space radiation hazards on mitochondrial Fe-S cluster stability, organellar DNA double-strand breaks, and the mobilization of dual-targeted homologous recombination repair machinery (RecA1, PolIA).
Key Biological Insights:
Key Discovery: Profound vulnerability of mitochondrial iron-sulfur [4Fe-4S] clusters in Complex I and Complex II to heavy ion oxidation.
Key Discovery: Strong induction of dual-targeted genome maintenance enzymes (RecA1 +1.15 log2FC, p = 0.0008).
Key Discovery: Mitochondria-to-nucleus retrograde stress wave triggering systemic antioxidant defenses.
Key Discovery: Enhanced stromule contact site dynamics between plastids and mitochondria under radiation damage.
Primary Literature & Mission Reports:
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Pre-Projected Organellar Pathway Maps
High-resolution vector maps showing spaceflight log2 fold-changes dynamically color-coded with WCAG AAA luminance-adaptive text contrast.
Hover over or click any pathway node in the map above to inspect locus ID, fold-change, significance, and biological role.
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Ranked Organellar Responders
All assayed mitochondrial, chloroplast, and peroxisomal loci in OSD-8, ranked by absolute fold-change.
| Rank | AGI Locus | Symbol | Subcompartment | Log2 Fold-Change | p-value | Pathway / Biological Role | Action |
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