{
  "preregistration": "PRE-REGISTRATION \u2014 written before the test was run, and not edited after.",
  "inputs": {
    "conservation_table": "data/external/Table_S8_organelle_conservation_final.csv",
    "conservation_rows": 1210,
    "distinct_genes": 832,
    "conserved_down": 343,
    "conserved_up": 247,
    "dropped_mixed_or_conflicting": 242,
    "uniprot_set_sizes": {
      "iron-sulfur": 71,
      "flavoprotein": 126,
      "heme": 137,
      "mitochondrion": 1505,
      "electron transport": 130
    }
  },
  "tests": [
    {
      "name": "primary: any spin-bearing cofactor, conserved-down vs conserved-up",
      "down_with": 13,
      "down_without": 330,
      "up_with": 6,
      "up_without": 241,
      "odds_ratio": 1.582,
      "ci95": [
        0.587,
        3.925
      ],
      "p": 0.4797391962865578,
      "significant": false
    },
    {
      "name": "class: iron-sulfur",
      "down_with": 5,
      "down_without": 338,
      "up_with": 4,
      "up_without": 243,
      "odds_ratio": 0.899,
      "ci95": [
        0.25,
        3.089
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "class: flavoprotein",
      "underpowered": true,
      "down_with": 4,
      "up_with": 0
    },
    {
      "name": "class: heme",
      "down_with": 4,
      "down_without": 339,
      "up_with": 2,
      "up_without": 245,
      "odds_ratio": 1.445,
      "ci95": [
        0.275,
        6.162
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Nucleus",
      "down_with": 5,
      "down_without": 162,
      "up_with": 1,
      "up_without": 39,
      "odds_ratio": 1.204,
      "ci95": [
        0.142,
        5.604
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Plasma membrane",
      "down_with": 0,
      "down_without": 59,
      "up_with": 1,
      "up_without": 122,
      "odds_ratio": 0.0,
      "ci95": [
        0.028,
        17.101
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Cytoskeleton",
      "down_with": 1,
      "down_without": 83,
      "up_with": 0,
      "up_without": 27,
      "odds_ratio": Infinity,
      "ci95": [
        0.039,
        24.966
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Cell wall/Extracellular matrix",
      "down_with": 0,
      "down_without": 46,
      "up_with": 0,
      "up_without": 34,
      "odds_ratio": NaN,
      "ci95": [
        0.014,
        38.328
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Extracellular",
      "down_with": 1,
      "down_without": 16,
      "up_with": 0,
      "up_without": 53,
      "odds_ratio": Infinity,
      "ci95": [
        0.378,
        250.345
      ],
      "p": 0.24285714285714277,
      "significant": false
    },
    {
      "name": "stratum: Membrane transport",
      "down_with": 3,
      "down_without": 44,
      "up_with": 0,
      "up_without": 3,
      "odds_ratio": Infinity,
      "ci95": [
        0.023,
        12.934
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Ribosome",
      "down_with": 0,
      "down_without": 16,
      "up_with": 0,
      "up_without": 15,
      "odds_ratio": NaN,
      "ci95": [
        0.018,
        50.316
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Endoplasmic Reticulum",
      "down_with": 4,
      "down_without": 17,
      "up_with": 1,
      "up_without": 5,
      "odds_ratio": 1.176,
      "ci95": [
        0.118,
        7.559
      ],
      "p": 1.0,
      "significant": false
    },
    {
      "name": "stratum: Chloroplast/Plastid",
      "underpowered": true,
      "n": 13
    },
    {
      "name": "stratum: Lipid particle",
      "underpowered": true,
      "n": 13
    },
    {
      "name": "stratum: Proteasome",
      "underpowered": true,
      "n": 6
    },
    {
      "name": "stratum: Peroxisome",
      "underpowered": true,
      "n": 6
    },
    {
      "name": "stratum: Golgi apparatus",
      "underpowered": true,
      "n": 2
    }
  ],
  "confound": {
    "mitochondrion": {
      "spin_genes_in_universe": 19,
      "also_in_context": 10,
      "fraction": 0.5263
    },
    "electron transport": {
      "spin_genes_in_universe": 19,
      "also_in_context": 3,
      "fraction": 0.1579
    }
  },
  "power": {
    "curve": [
      {
        "true_odds_ratio": 1.5,
        "power": 0.09
      },
      {
        "true_odds_ratio": 2.0,
        "power": 0.26
      },
      {
        "true_odds_ratio": 2.5,
        "power": 0.494
      },
      {
        "true_odds_ratio": 3.0,
        "power": 0.691
      },
      {
        "true_odds_ratio": 4.0,
        "power": 0.932
      }
    ],
    "min_detectable_or_at_80pct_power": 4.0
  }
}